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Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Cell-penetrating peptide [WR]<sub>5</sub> has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one lysine to enable the conjugation wi...

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Principais autores: Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Kumar Tiwari
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2019-04-01
Series:Molecules
Assuntos:
cell-penetrating peptide
conjugate
camptothecin
cytotoxicity
MCF-7
paclitaxel
solubility
Acceso en liña:https://www.mdpi.com/1420-3049/24/7/1427
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