Neocortical layer-5 tLTD relies on non-ionotropic presynaptic NMDA receptor signaling

In the textbook view, NMDA receptors (NMDARs) act as coincidence detectors in Hebbian plasticity by fluxing Ca2+ when simultaneously depolarized and glutamate bound. Hebbian coincidence detection requires that NMDARs be located postsynaptically, but enigmatic presynaptic NMDARs (preNMDARs) also exis...

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Egile Nagusiak:	Aurore Thomazeau, Sabine Rannio, Jennifer A Brock, Hovy Ho-Wai Wong, Per Jesper Sjöström
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	eLife Sciences Publications Ltd 2025-07-01
Saila:	eLife
Gaiak:	long-term plasticity STDP LTD LTP NMDA receptor
Sarrera elektronikoa:	https://elifesciences.org/articles/106284
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