Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells
Abstract Background Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues. Results Here, we use computational modeling and single-cell ge...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BMC
2025-03-01
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| Seri Bilgileri: | Genome Biology |
| Konular: | |
| Online Erişim: | https://doi.org/10.1186/s13059-025-03540-7 |
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