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CDK4/6 Inhibitors in Combination Therapies: Better in Company Than Alone: A Mini Review

The cyclin D-CDK4/6 complexes play a pivotal role in controlling the cell cycle. Deregulation in cyclin D-CDK4/6 pathway has been described in many types of cancer and it invariably leads to uncontrolled cell proliferation. Many efforts have been made to develop a target therapy able to inhibit CDK4...

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Principais autores: Gian Luca Rampioni Vinciguerra, Maura Sonego, Ilenia Segatto, Alessandra Dall’Acqua, Andrea Vecchione, Gustavo Baldassarre, Barbara Belletti
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
coleção:Frontiers in Oncology
Assuntos:
CDK4/6 inhibitors
drug resistance
small inhibitors
chemotherapy
combination therapy
endocrine therapy
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2022.891580/full
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