Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition
The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated cellular proteins. Removal of ubiquitin chains from targeted substrates at the proteasome is a prerequisite for substrate processing and is accomplished by Rpn11, a deubiquitinase within the ‘lid’ sub...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications Ltd
2016-01-01
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| Collection: | eLife |
| Sujets: | |
| Accès en ligne: | https://elifesciences.org/articles/13027 |
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