Efficacy and safety of hepatic arterial infusion chemotherapy plus lenvatinib and PD-1/PD-L1 inhibitors versus systemic chemotherapy plus lenvatinib and PD-1/PD-L1 inhibitors in advanced unresectable cholangiocarcinoma: a retrospective cohort study

Abstract Background Hepatic arterial infusion chemotherapy (HAIC) provides sustained high intrahepatic drug exposure with limited systemic toxicity, potentially enhancing antigen release and immune sensitization. This study compared the efficacy and safety of HAIC combined with lenvatinib and PD-1/P...

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Detalhes bibliográficos

Principais autores:	Zhenzhen Zhang, Meixia Wang, Guobin Chen, Yanfang Wu, Xiaochun Chen, Xinkun Guo, Boheng Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2025-12-01
coleção:	Cancer Immunology, Immunotherapy
Assuntos:	Intrahepatic cholangiocarcinoma HAIC Lenvatinib PD-1/PD-L1 inhibitor Survival Biomarkers
Acesso em linha:	https://doi.org/10.1007/s00262-025-04255-1
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