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Effect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline

ABSTRACT Sertraline is commonly used to treat mental health conditions in youth. However, its tolerability and efficacy vary between individuals, partly due to interindividual differences in drug metabolism. This study assessed the individual and combined impact of genetic variation in cytochrome P4...

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Main Authors: Samuel Gerlach, Abdullah Al Maruf, Sarker M. Shaheen, Ryden McCloud, Madison Heintz, Laina McAusland, Paul D. Arnold, Chad A. Bousman
Format: Artigo
Language:Inglês
Published: Wiley 2026-05-01
Series:Clinical and Translational Science
Subjects:
adolescents
children
emerging adults
pharmacogenetics
psychiatry
sertraline
Online Access:https://doi.org/10.1111/cts.70590
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