On-target restoration of a split T cell-engaging antibody for precision immunotherapy

The restriction of appropriate tumour-specific antigens is a current limitation for T cell-engaging immunotherapy. Here, the authors have designed a new system constituted by two halve antibodies, which engage T cells once binding to two different antigens, to specifically eliminate double positive...

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Detalhes bibliográficos

Principais autores:	Agnes Banaszek, Thomas G. P. Bumm, Boris Nowotny, Maria Geis, Kim Jacob, Matthias Wölfl, Johannes Trebing, Kirstin Kucka, Dina Kouhestani, Tea Gogishvili, Bastian Krenz, Justina Lutz, Leo Rasche, Dirk Hönemann, Hannes Neuweiler, Julia C. Heiby, Ralf C. Bargou, Harald Wajant, Hermann Einsele, Gert Riethmüller, Gernot Stuhler
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2019-11-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-019-13196-0
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