Investigating the versatility of cytochalasan cytochrome P450 monooxygenases using combinatorial biosynthesis reveals stereochemical restrictions

Abstract Background Cytochalasans are a large family of fungal metabolites which inhibit actin polymerization and ultimately lead to a broad range of biological effects in different assays. Investigations into the biosynthesis of cytochalasans has revealed that the cytochrome P450 monooxygenase (P45...

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Principais autores:	Lei Li, Tahir Ali, Jacob Goralczyk, Sameera Jayasundara, Ayan Paul, Marcelo Rodrigues de Amorim, Christine Beemelmanns, Elizabeth Skellam
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-06-01
Series:	Fungal Biology and Biotechnology
Assuntos:	Biocatalysis Combinatorial biosynthesis Cytochalasans Cytochrome P450 monooxygenases.
Acceso en liña:	https://doi.org/10.1186/s40694-026-00214-2
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