Identification and characterization of binders to a cryptic and functional pocket in KRAS

Abstract RAS proteins control cell proliferation and activating mutations are collectively the most frequent oncogenic event observed in cancer patients, justifying investments into multiple drug discovery efforts. While RAS-directed therapeutic agents targeting either the inactive GDP-bound or the...

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Detalles Bibliográficos

Principais autores:	Kim S. Beyer, Jessica Klein, Stéphanie Katz, Patrick Welker, Mylene Lanter, Daniel Guthy, Kerstin Pollehn, Aurélie Gluck-Gadé, Melusine Bleu, Jessica Desogus, Marc Hattenberger, Damiano Borrello, Wassim Abdul Rahman, Florence Zink, Nils Ostermann, Wolfgang Jahnke, Christoph E. Dumelin, Lukas Leder, Oliver Esser, Lionel Muller, Andreas Marzinzik, Regis Cébé, Kathrin Müller, Giorgio G. Galli, Luca Tordella, Simona Cotesta, Saskia M. Brachmann, Sauveur-Michel Maira
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-12-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-65844-3
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