Terminally exhausted CD8+ T cells in solid tumors: biology, biomarker potential and translational tools for precision oncology

Terminally exhausted CD8+ T cells (Ttex) are emerging as clinically relevant immune subsets across solid tumors, marked by sustained inhibitory receptor expression, loss of TCF1, and limited proliferative capacity. Once considered functionally inert, Ttex are now recognized for their residual cytoto...

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Detalhes bibliográficos

Principais autores:	Xuejun Guo, Shuhan Ma, Jingwen Wang, Yilin Fu, Wenxue Ma
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-01-01
coleção:	Frontiers in Immunology
Assuntos:	digital pathology immunotherapy biomarkers precision oncology T cell exhaustion terminally exhausted CD8⁺ T cells tumor microenvironment
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1709852/full
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