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MRI-based radiomics for noninvasive prediction of T790M resistance mutation in lung cancer spinal metastases: an exploratory study

BackgroundThe T790M mutation is a significant mechanism of acquired resistance to EGFR-TKIs in non-small cell lung cancer (NSCLC). Its noninvasive detection in spinal metastases remains challenging due to tumour heterogeneity and limitations of current diagnostic methods. This study aimed to develop...

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Principais autores: Xiaoya Zhou, Jiashi Zheng, Hua Ai, Chunna Yang, Jiahui Wang, Yiyao Sun, Lijun Jin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-10-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
bone metastases
radiomics
intratumoral heterogeneity
targeted therapy
interpretability
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2025.1673498/full
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