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Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome

Abstract Background Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating regeneration of the bone marrow (BM), namely the hematopoietic stem and progenitor cells (HSPCs), is key in mitigating ARS and mu...

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Автори: Justin Vercellino, Beata Małachowska, Shilpa Kulkarni, Brett I. Bell, Shahin Shajahan, Kosaku Shinoda, Gary Eichenbaum, Amit K. Verma, Sanchita P. Ghosh, Weng-Lang Yang, Paul S. Frenette, Chandan Guha
Формат: Artigo
Мова:Inglês
Опубліковано: BMC 2024-04-01
Серія:Stem Cell Research & Therapy
Предмети:
Hematopoietic acute radiation syndrome
Total body irradiation
Bone marrow
Mesenchymal stromal cells
Endothelial cells
Thrombopoietin mimetic
Онлайн доступ:https://doi.org/10.1186/s13287-024-03734-z
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