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Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist

Background In contrast to immune checkpoint inhibitors, the use of antibodies as agonists of immune costimulatory receptors as cancer therapeutics has largely failed. We sought to address this problem using a new class of modular synthetic drugs, termed tumor-targeted immune cell agonists (TICAs), b...

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Autori principali: Sailaja Battula, Kristen Hurov, Johanna lahdenranta, Gemma Mudd, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Marianna Kleyman, Jessica Kublin, Liuhong Chen, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen, Rachel Dods, Rachid Lani, Katerine Van Rietschoten, Tom Stephen, Fanglei You
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2021-01-01
Serie:Journal for ImmunoTherapy of Cancer
Accesso online:https://jitc.bmj.com/content/9/1/e001762.full
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