Accelerated reprogramming of hiPSCs into functional brain endothelial-like cells using multiplexed CRISPR activation

Abstract Human induced pluripotent stem cells (hiPSCs) offer a renewable and scalable source for generating brain endothelial cells (BECs), enabling the development of in vitro blood-brain barrier (BBB) models that closely reflect human physiology. In this study, we demonstrate a streamlined differe...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Roy W. Hwang, Yara Khalil, Ewa Baumann, Junzhuo Huang, Claudie Charlebois, Marina Rukhlova, Tyler M. Renner, Ziying Liu, Anna Jezierski, Mads Kærn, Will J. Costain
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-04-01
Serija:	Scientific Reports
Teme:	CRISPR Brain endothelial cells Blood-brain barrier iPSC Transcriptional reprogramming Synthetic biology
Online dostop:	https://doi.org/10.1038/s41598-026-46961-5
Oznake:	Označite Brez oznak, prvi označite!