Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice

Clonal hematopoiesis (CH) increases inflammasome-linked atherosclerosis, but the mechanisms by which CH mutant cells transmit inflammatory signals to nonmutant cells are largely unknown. To address this question, we transplanted 1.5% Jak2V617F (Jak2VF) bone marrow (BM) cells with 98.5% WT BM cells i...

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Hlavní autoři:	Wenli Liu, Brian D. Hardaway, Eunyoung Kim, Jessica Pauli, Justus Leonard Wettich, Mustafa Yalcinkaya, Cheng-Chieh Hsu, Tong Xiao, Muredach P. Reilly, Ira Tabas, Lars Maegdefessel, Kai Schlepckow, Christian Haass, Nan Wang, Alan R. Tall
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 2025-01-01
Edice:	The Journal of Clinical Investigation
Témata:	Vascular biology
On-line přístup:	https://doi.org/10.1172/JCI182939
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