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RagC GTPase regulates mTOR to promote chemoresistance in senescence-like HepG2 cells

Radiotherapy and chemotherapy can arrest cancer cells in a senescence-like state, which can lead to therapy resistance and cancer relapse. mTOR is hyperactivated in senescent cells but the mechanisms remain unclear. In this study, we examine the roles of several mTOR-regulated GTPases in senescence-...

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Bibliografische gegevens
Hoofdauteurs: Wei Jiang, Zhenglin Ou, Qin Zhu, Hongyan Zai
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2022-10-01
Reeks:Frontiers in Physiology
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Online toegang:https://www.frontiersin.org/articles/10.3389/fphys.2022.949737/full
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