Histone methyltransferases MLL2 and SETD1A/B play distinct roles in H3K4me3 deposition during the transition from totipotency to pluripotency

Abstract In early mammalian embryogenesis, a shift from non-canonical histone H3 lysine 4 trimethylation (H3K4me3) linked to transcriptional repression to canonical H3K4me3 indicating active promoters occurs during zygotic genome activation (ZGA). However, the mechanisms and roles of these H3K4me3 s...

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Autors principals:	Jingjing Zhang, Qiaoran Sun, Liang Liu, Shichun Yang, Xia Zhang, Yi-Liang Miao, Xin Liu
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2024-12-01
Col·lecció:	The EMBO Journal
Matèries:	H3K4me3 MLL2 SETD1A/B Zygotic Genome Activation First Lineage Segregation
Accés en línia:	https://doi.org/10.1038/s44318-024-00329-5
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