Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling

Abstract The androgen receptor (AR) transduces the effects of circulating and tumor-derived androgens to the nucleus through ligand-induced changes in protein conformation, localization, and chromatin engagement. Defining how these events are integrated with signal transduction is critical to unders...

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Autors principals:	Krzysztof Wierbiłowicz, Chun-Song Yang, Ahmed Almaghasilah, Patryk A Wesołowski, Philipp Pracht, Natalia M Dworak, Jack Masur, Sven Wijngaarden, Dmitri V Filippov, David J Wales, Joshua B Kelley, Aakrosh Ratan, Bryce M Paschal
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2025-07-01
Col·lecció:	The EMBO Journal
Matèries:	AR ADP-ribosylation Ubiquitin DTX2 RBN2397
Accés en línia:	https://doi.org/10.1038/s44318-025-00510-4
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