The ERN1 signaling pathway of unfolded protein controls the expression of EDEM1 and its hypoxic regulation in glioblastoma cells

Objective. For the effective growth of malignant tumors, including glioblastoma, the necessary factors involve endoplasmic reticulum (ER) stress, hypoxia, and the availability of nutrients, particularly glucose. The ER degradation enhancing alpha-mannosidase like protein 1 (EDEM1) is involved in ER-...

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Autori principali:	Minchenko Oleksandr H., Hrebennykova Vita O., Viletska Yuliia M., Hnatiuk Oksana S., Sliusar Myroslava Y., Kozynkevych Halyna E., Minchenko Dmytro O.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Sciendo 2025-01-01
Serie:	Endocrine Regulations
Soggetti:	edem1 gene expression ern1 knockdown ern1 protein kinase hypoxia nutrient deprivation glioblastoma cells
Accesso online:	https://doi.org/10.2478/enr-2025-0001
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