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Colonic Dopaminergic Neurons Changed Reversely With Those in the Midbrain via Gut Microbiota-Mediated Autophagy in a Chronic Parkinson’s Disease Mice Model

The role of gut-brain axis in the pathogenesis of Parkinson’s disease (PD) have become a research hotspot, appropriate animal model to study gut-brain axis in PD is yet to be confirmed. Our study employed a classical PD mice model achieved by chronic MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin...

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Huvudupphov: Xin Liu, Zhong-Rui Du, Xiong Wang, Kar-Him Luk, Cheuk-Hin Chan, Xu Cao, Qing Zhao, Fang Zhao, Wing-Tak Wong, Ka-Hing Wong, Xiao-Li Dong
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2021-04-01
Serie:Frontiers in Aging Neuroscience
Ämnen:
Parkinson’s disease
dopamine
tyrosine hydroxylase
autophagy
apoptosis
short chain fatty acids
Länkar:https://www.frontiersin.org/articles/10.3389/fnagi.2021.649627/full
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