A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function

Abstract Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococca...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Wael Bahnan, Lotta Happonen, Hamed Khakzad, Vibha Kumra Ahnlide, Therese de Neergaard, Sebastian Wrighton, Oscar André, Eleni Bratanis, Di Tang, Thomas Hellmark, Lars Björck, Oonagh Shannon, Lars Malmström, Johan Malmström, Pontus Nordenfelt
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2022-12-01
Schriftenreihe:	EMBO Molecular Medicine
Schlagworte:	dual‐Fab immune function monoclonals Streptococcus therapeutics
Online-Zugang:	https://doi.org/10.15252/emmm.202216208
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