Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors

Abstract Background Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potential, however, has been bottlenecked in a mostly laboratory setting due...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Breanna S. Borys, Tiffany Dang, Tania So, Leili Rohani, Tamas Revay, Tylor Walsh, Madalynn Thompson, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee, Michael S. Kallos
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2021-01-01
Sarja:	Stem Cell Research & Therapy
Aiheet:	Induced pluripotent stem cells Vertical-wheel bioreactor Computational fluid dynamics Scale-up Single cell Harvest
Linkit:	https://doi.org/10.1186/s13287-020-02109-4
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