Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation

Abstract Background Spindle and kinetochore-associated complex subunit 3 (SKA3) plays an important role in cell proliferation by regulating the separation of chromosomes and their division into daughter cells. Previous studies demonstrated that SKA3 was strongly implicated in tumor development and p...

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Autori principali:	Yananlan Chen, Xiao Xu, Yirui Wang, Yaodong Zhang, Tao Zhou, Wangjie Jiang, Ziyi Wang, Jiang Chang, Shuochen Liu, Ruixiang Chen, Jijun Shan, Jifei Wang, Yuming Wang, Changxian Li, Xiangcheng Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-10-01
Serie:	Journal of Experimental & Clinical Cancer Research
Soggetti:	SKA3 Hypoxia HIF-1a Deubiquitylation Cholangiocarcinoma
Accesso online:	https://doi.org/10.1186/s13046-023-02842-7
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