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Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation

Abstract Background Ischemic stroke triggers excessive microglial activation and sustained neuroinflammation, driving secondary neuronal injury. Recent evidence suggests that dysfunction of the autophagy-lysosome system may be a crucial factor sustaining microglial pro-inflammatory responses, yet th...

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Asıl Yazarlar: Siyi Xu, Pinyi Liu, Junqiu Jia, Min Sun, Feiyu Ma, Rui Mao, Huiqin Li, Senlin Ji, Xinyu Bao, Shengnan Xia, Yun Xu, Xiang Cao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2025-10-01
Seri Bilgileri:Journal of Neuroinflammation
Konular:
Ischemic stroke
Microglia
NLRC5
Autophagy
Lysosomal dysfunction
Online Erişim:https://doi.org/10.1186/s12974-025-03585-2
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