Structural basis for substrate-induced activation of 3-hydroxybutyryl-CoA dehydrogenase from Faecalibacterium prausnitzii L2-6

Abstract Dysbiosis of the gut microbiota has increasingly been associated with atopic dermatitis (AD), a chronic inflammatory dermatological disorder. Butyrate, a short-chain fatty acid recognized for its significant anti-inflammatory capabilities, has garnered particular interest among gut microbia...

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Principais autores:	Byeongmin Shin, Seonha Park, Hosam Ki, Hye-Jin Kim Hawkes, Kyuhyeon Bang, Ingyo Park, Sulhee Kim, Kwang Yeon Hwang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2025-10-01
coleção:	Applied Biological Chemistry
Assuntos:	Atopic dermatitis 3-hydroxybutyryl-CoA dehydrogenase Butyrate Clamp-lid domain Acetoacetyl-CoA
Acesso em linha:	https://doi.org/10.1186/s13765-025-01048-z
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