Noninvasive MGMT-promotor methylation prediction in high grade gliomas using conventional MRI and deep learning-based segmentations

Background/objectivesHigh grade gliomas (HGG) are aggressive brain tumors, most frequently glioblastoma and astrocytoma grade 4. Methylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter in HGG is crucial for temozolomide efficacy. As MGMT promoter methylation (MGMTpm) assessment require...

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Autors principals:	Edin Zahirovic, Tim Salomonsson, Malte Knutsson, Xavier Saenz Sarda, Jimmy Lätt, Sara Kinhult, Mattias Belting, Anna Rydelius, Johan Bengzon, Linda Knutsson, Pia C. Sundgren
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-12-01
Col·lecció:	Frontiers in Neuroscience
Matèries:	MGMT methylation MRI deep learning high grade glioma (HGG)
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1689003/full
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