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Approaches to Detecting False Positives in Yeast Two-Hybrid Systems

While many novel associations predicted by two-hybrid library screens reflect actual biological associations of two proteins in vivo, at times the functional co-relevance of two proteins scored as interacting in the two-hybrid system is unlikely. The reason for this positive score remains obscure, w...

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Auteurs principaux: Ilya Serebriiskii, Joanne Estojak, Michelle Berman, Erica A. Golemis
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis Group 2000-02-01
Collection:BioTechniques
Accès en ligne:https://www.future-science.com/doi/10.2144/00282rr03
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