AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway

Abstract Obesity and diabetes are risk factors for hepatocellular carcinoma (HCC); however, the underlying mechanisms are yet to be elucidated. Adeno‐associated virus (AAV) frequently infects humans and has been widely used in gene therapy, but the risk of AAV infection such as HCC should be further...

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Hlavní autoři:	Yalan Cheng, Zhentong Zhang, Peidong Gao, Hejin Lai, Wuling Zhong, Ning Feng, Yale Yang, Huimin Yu, Yali Zhang, Yumo Han, Jieya Dong, Zhishui He, Rui Huang, Qiwei Zhai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2023-06-01
Edice:	EMBO Molecular Medicine
Témata:	diabetes HCC necroptosis obesity rAAV
On-line přístup:	https://doi.org/10.15252/emmm.202217230
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