Targeting A2M-LRP1 reverses uterine spiral artery remodeling disorder and alleviates the progression of preeclampsia

Abstract Background Patients with early-onset preeclampsia (EOPE) have a most severe disease state. a2-macroglobulin (A2M) play a crucial role in the pathogenesis of EOPE, but its molecular basis and therapeutic potential remain unclear. This study aimed to elucidate the mechanisms of A2M in EOPE pr...

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Detalhes bibliográficos

Principais autores:	Zhengrui Huang, Ping Zhang, Ruiping Chen, Lu Sun, Jingyun Wang, Ruiling Yan, Mengyuan Liu, Yuzhen Ding, Jian Wang, Jiachun Wei, Wanchang Yin, Xinyao Lu, Guang Wang, Xuesong Yang, Ruiman Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
coleção:	Cell Communication and Signaling
Assuntos:	Preeclampsia Α2-macroglobulin Smooth muscle cells Uterine spiral artery Phenotype switching
Acesso em linha:	https://doi.org/10.1186/s12964-025-02060-y
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