CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma

Cluster of differentiation 47 (CD47) is a transmembrane protein highly expressed in tumor cells that interacts with signal regulatory protein alpha (SIRPα) and triggers a “don’t eat me” signal to the macrophage, inhibiting phagocytosis and enabling tumor escape from immunosurveillance. The CD47-SIRP...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Taylor & Francis Group 2024-12-01
سلاسل:	mAbs
الموضوعات:	CD20 CD47 detune non-Hodgkin’s lymphoma phagocytosis
الوصول للمادة أونلاين:	https://www.tandfonline.com/doi/10.1080/19420862.2024.2310248
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!