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Non-Clinical Safety of GRAd Vector-Based COVID-19 and HIV Vaccines Supports a Platform Regulatory Approach

<b>Background/Objectives</b>: The rapid development of safe and efficacious vaccines is often hindered by extensive, mandated non-clinical safety evaluations in animals. With the aim to provide scientific evidence supporting a “vaccine platform approach”, here we present the complete non-clinical st...

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Principais autores: Reji Paalangara, Stephanie Gohin, Alexis Menard, Charlotte Amy, Wahiba Berrabah, Alexandra Rogue, Matthew A. Getz, Aljawharah Alrubayyi, Simone Battella, Angelo Raggioli, Michela Gentile, Anthea Di Rita, Alessia Noto, Giuseppina Miselli, Fabiana Grazioli, Federico Napolitano, Dhurata Sowcik, Marco Soriani, Benjamin Chmielewski, Lebohang Molife, Vincent Muturi-Kioi, Azure Tariro Makadzange, Gaurav D. Gaiha, Philippe Ancian, Jim Ackland, Antonella Folgori, Stefano Colloca, Stefania Capone
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-02-01
coleção:Vaccines
Assuntos:
gorilla adenovirus
viral vectors
vaccine platform
non-clinical safety
toxicity
biodistribution
Acesso em linha:https://www.mdpi.com/2076-393X/14/2/157
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