USP5 regulates ferroptosis in colorectal cancer by targeting the YBX3/SLC7A11 axis through lysosomal degradation

Abstract Colorectal cancer (CRC) is the third most common cancer worldwide and a significant public health threat. Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a promising therapeutic target in CRC treatment. Despite its significant clinical potential, the precise regu...

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Autores principales:	Haowen Qiu, Yi Liu, Haimeng Zhou, Lingjuan Hu, Wei Qi, Honglu Ma, Yaoyi Liu, Le Li, Nanyang Yang, Meiqin Huang, Runlei Du, Lijuan Meng, Feng Shi, Baiqi Wang, Li Yu, Xiaodong Zhang, Guoqing Li
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2025-11-01
Colección:	Cell Death and Disease
Acceso en línea:	https://doi.org/10.1038/s41419-025-08146-2
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