Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2

Background & Aims: Exploiting key regulators responsible for hepatocarcinogenesis is of great importance for the prevention and treatment of hepatocellular carcinoma (HCC). However, the key players contributing to hepatocarcinogenesis remain poorly understood. We explored the molecular mechanism...

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Autores principales:	Siying Wang, Yangyang Zhou, Ruobing Yu, Jing Ling, Botai Li, Chen Yang, Zhuoan Cheng, Ruolan Qian, Zhang Lin, Chengtao Yu, Jiaojiao Zheng, Xingling Zheng, Qi Jia, Wei Wu, Qiangxin Wu, Mengnuo Chen, Shengxian Yuan, Wei Dong, Yaoping Shi, Robin Jansen, Yujun Hao, Ming Yao, Wenxin Qin, Haojie Jin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2023-10-01
Colección:	JHEP Reports
Materias:	Formimidoyltransferase cyclodeaminase Hepatocarcinogenesis Lipid metabolism Tumour suppressor
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S258955592300174X
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