An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells

Abstract Aberrant Ras homologous (Rho) GTPase signalling is a major driver of cancer metastasis, and GTPase-activating proteins (GAPs), the negative regulators of RhoGTPases, are considered promising targets for suppressing metastasis, yet drug discovery efforts have remained elusive. Here, we repor...

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Detalhes bibliográficos

Principais autores:	Despoina Kyriazi, Lea Voth, Almke Bader, Wiebke Ewert, Juliane Gerlach, Kerstin Elfrink, Peter Franz, Mariana I. Tsap, Bastian Schirmer, Julia Damiano-Guercio, Falk K. Hartmann, Masina Plenge, Azam Salari, Dennis Schöttelndreier, Katharina Strienke, Nadine Bresch, Claudio Salinas, Herwig O. Gutzeit, Nora Schaumann, Kais Hussein, Heike Bähre, Inga Brüsch, Peter Claus, Detlef Neumann, Manuel H. Taft, Halyna R. Shcherbata, Anaclet Ngezahayo, Martin Bähler, Mahdi Amiri, Hans-Joachim Knölker, Matthias Preller, Georgios Tsiavaliaris
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-54181-6
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