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Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival

Abstract Background The anticancer drug paclitaxel is primarily metabolized in the liver. Previous studies have indicated a correlation between impaired liver function and paclitaxel toxicity, which may indicate dose reduction. Since the evidence is limited, the aim of this study was to investigate...

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Autori principali: Marieke Schmidt, Robin Vernooij, Merel van Nuland, Erin Smeijsters, Lot Devriese, Nadia Haj Mohammad, Thom Hermens, Julian Stammers, Christina Swart, Toine Egberts, Saskia Haitjema, Laureen Lammers
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-12-01
Serie:BMC Cancer
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Accesso online:https://doi.org/10.1186/s12885-024-13330-2
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