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Differential transcriptional control of hematopoiesis in congenital and cyclic neutropenia patients harboring <i>ELANE</i> mutations

Mutations in the ELANE gene, encoding the neutrophil elastase (NE) protein, are responsible for most cyclic neutropenia (CyN) cases and approximately 25% of congenital neutropenia (CN) cases. In CN and in CyN, a median of 2.8% of CD34+ cells were early CD49f+ hematopoietic stem cells (eHSC) that di...

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Principais autores: Alexander Zeidler, Natalia Borbaran-Bravo, Benjamin Dannenmann, Malte Ritter, Masoud Nasri, Maksim Klimiankou, Sergey Kandabarau, Azadeh Zahabi, Josef König, Cornelia Zeidler, Julia Skokowa, Karl Welte
פורמט: Artigo
שפה:Inglês
יצא לאור: Ferrata Storti Foundation 2023-10-01
סדרה:Haematologica
גישה מקוונת:https://haematologica.org/article/view/11314
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