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PFKFB3 Inhibitor 3PO Reduces Cardiac Remodeling after Myocardial Infarction by Regulating the TGF-β1/SMAD2/3 Pathway

Adverse cardiac remodeling, including cardiac fibrosis, after myocardial infarction (MI) is a major cause of long-term heart failure. 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), an enzyme that regulates glucose metabolism, also plays an important role in various fibrotic and card...

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Principais autores: Qian Yang, Xiao Zong, Lingfang Zhuang, Roubai Pan, Xierenayi Tudi, Qin Fan, Rong Tao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-07-01
Serier:Biomolecules
Fag:
PFKFB3
myocardial infarction (MI)
cardiac remodeling
cardiac fibroblast
fibrosis
Online adgang:https://www.mdpi.com/2218-273X/13/7/1072
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