Spatiotemporal Regulation of Ligand Trafficking and TLR9 Activation by PIEZO1 in Human Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells (pDCs) are innate immune cells that produce type I interferons (IFNs) upon sensing nucleic acids via Toll-like receptor 9 (TLR9). Synthetic oligodeoxynucleotides CpGA and CpGB are widely used TLR9 agonists, yet only CpGA robustly induces IFN-α in pDCs. In contrast, CpGB...

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Bibliografske podrobnosti

Principais autores:	Shrestha Pattanayak, Deblina Raychaudhuri, Purbita Bandopadhyay, Upasana Mukhopadhyay, Tithi Mandal, Chinky Shiu Chen Liu, Nidhi Kalidas, Sumangal Roychowdhury, Krishnananda Chattopadhyay, Fnu Ashish, Bidisha Sinha, Dipyaman Ganguly
Format:	Artigo
Jezik:	Inglês
Izdano:	American Association for the Advancement of Science (AAAS) 2026-01-01
Serija:	Research
Online dostop:	https://spj.science.org/doi/10.34133/research.1067
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