Safety and efficacy of zolbetuximab plus chemotherapy for claudin 18 isoform 2-positive advanced gastric cancer: initial report of real-world experience

Abstract Purpose This study evaluated the safety and preliminary efficacy of zolbetuximab plus chemotherapy in patients with claudin 18 isoform 2 (CLDN18.2)-positive advanced gastric cancer (AGC). Methods This single-institutional retrospective study enrolled patients with HER2-negative CLDN18.2-pos...

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Auteurs principaux:	Keitaro Shimozaki, Akira Ooki, Shota Fukuoka, Hiroki Osumi, Kaoru Yoshikawa, Koichiro Yoshino, Shohei Udagawa, Takeru Wakatsuki, Eiji Shinozaki, Mariko Ogura, Keisho Chin, Kensei Yamaguchi
Format:	Artigo
Langue:	Inglês
Publié:	Springer 2025-12-01
Collection:	Journal of Cancer Research and Clinical Oncology
Sujets:	Gastric or gastroesophageal junction cancer Zolbetuximab Claudin 18 isoform 2 Gastrointestinal toxicity Molecular agent
Accès en ligne:	https://doi.org/10.1007/s00432-025-06406-4
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