Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification

Abstract Phosphoprotein phosphatases (PPPs) regulate major signaling pathways, but the determinants of phosphatase specificity are poorly understood. This is because methods to investigate this at scale are lacking. Here, we develop a novel in vitro assay, MRBLE:Dephos, that allows multiplexing of d...

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Detalhes bibliográficos

Principais autores:	Jamin B Hein, Hieu T Nguyen, Dimitriya H Garvanska, Isha Nasa, Thomas Kruse, Yinnian Feng, Blanca Lopez Mendez, Norman Davey, Arminja N Kettenbach, Polly M Fordyce, Jakob Nilsson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2023-12-01
coleção:	Molecular Systems Biology
Assuntos:	mitotic exit MRBLE:Dephos MRBLE‐Pep protein phosphatase substrates
Acesso em linha:	https://doi.org/10.15252/msb.202311782
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