Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis

Anti-citrullinated protein autoantibodies promote inflammation and joint tissue injury and define a poor prognostic group of patients with rheumatoid arthritis (RA). Citrullinated autoantigens that drive this autoimmune response are generated by peptidylarginine deiminase (PAD) enzymes, which are pr...

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Hauptverfasser:	Gary P. Sims, Lacie Scaletta, John Andrews, Dorothy A. Sims, Martin Strain, Anna Sigurdardottir, Teneema Kuriakose, Elizabeth England, Lichchavi Rajasinghe, Fanyi Jiang, Ximing Xiong, Frances Neal, Lisa Vinall, Philip Newton, Elin Boger, Chong Kim, Helena Dahlbäck, Susanne Prothon, Jacob Leander, Erika Darrah, Mia Collins, Garry Douglas, Nicholas White, Katie Day, Katherine A. Vousden, Catherine E. Huntington, David Close
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2026-12-01
Schriftenreihe:	mAbs
Schlagworte:	Bispecific PAD2 PAD4 rheumatoid arthritis AZD1163
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/19420862.2026.2657629
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