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Increased expression of the immunoproteasome subunits PSMB8 and PSMB9 by cancer cells correlate with better outcomes for triple-negative breast cancers

Abstract Proteasome dependency is a feature of many cancers that can be targeted by proteasome inhibitors. For some cancer types, notably breast cancer and triple-negative breast cancer (TNBC), high mRNA expression of a modified form of the proteasome, called the immunoproteasome (ImP), correlates w...

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Principais autores: Karen Geoffroy, Bruna Araripe Saraiva, Melissa Viens, Delphine Béland, Marie-Claude Bourgeois-Daigneault
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2023-02-01
coleção:Scientific Reports
Acesso em linha:https://doi.org/10.1038/s41598-023-28940-2
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