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Targeted RNA next generation sequencing analysis of cervical smears can predict the presence of hrHPV-induced cervical lesions

Abstract Background Because most cervical cancers are caused by high-risk human papillomaviruses (hrHPVs), cervical cancer prevention programs increasingly employ hrHPV testing as a primary test. The high sensitivity of HPV tests is accompanied by low specificity, resulting in high rates of overdiag...

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Main Authors: Karolina M. Andralojc, Duaa Elmelik, Menno Rasing, Bernard Pater, Albert G. Siebers, Ruud Bekkers, Martijn A. Huynen, Johan Bulten, Diede Loopik, Willem J. G. Melchers, William P. J. Leenders
Format: Artigo
Language:Inglês
Published: BMC 2022-06-01
Series:BMC Medicine
Subjects:
Cervical intraepithelial neoplasia
High risk human papilloma virus
Machine learning
Screening
Targeted RNA sequencing
Online Access:https://doi.org/10.1186/s12916-022-02386-1
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