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Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro

Free fatty acids (FFA), hyperglycemia, and inflammatory cytokines are major mediators of β-cell toxicity in type 2 diabetes mellitus, impairing mitochondrial metabolism. Glutaredoxin 5 (Glrx5) is a mitochondrial protein involved in the assembly of iron–sulfur clusters required for complexes of the r...

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Principais autores: Sebastian Friedrich Petry, Axel Römer, Divya Rawat, Lara Brunner, Nina Lerch, Mengmeng Zhou, Rekha Grewal, Fatemeh Sharifpanah, Heinrich Sauer, Gunter Peter Eckert, Thomas Linn
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-04-01
Series:Antioxidants
Assuntos:
glutaredoxin
β-cell
high fat diet
diabetes
obesity
mitochondria
Acceso en liña:https://www.mdpi.com/2076-3921/11/4/788
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