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Decreased Taxon-Specific IgA Response in Relation to the Changes of Gut Microbiota Composition in the Elderly

Gut microbiota is known to change with aging; however, the underlying mechanisms have not been well elucidated. Immunoglobulin A (IgA) is the dominant class of antibody secreted by the intestinal mucosa, and are thought to play a key role in the regulation of the gut microbiota. T cells regulate the...

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Principais autores: Hirosuke Sugahara, Shinsaku Okai, Toshitaka Odamaki, Chyn B. Wong, Kumiko Kato, Eri Mitsuyama, Jin-Zhong Xiao, Reiko Shinkura
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017-09-01
Serier:Frontiers in Microbiology
Fag:
gut microbiota
aging
IgA-seq
IgA
Enterobacteriaceae
Clostridiaceae
Online adgang:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01757/full
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