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Disruption of CTCF-YY1-dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription.

The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted. Upon epithelial differentiation, E6/E7 transcription is increased through unknown mechanisms to drive cellular prolif...

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Principais autores: Ieisha Pentland, Karen Campos-León, Marius Cotic, Kelli-Jo Davies, C David Wood, Ian J Groves, Megan Burley, Nicholas Coleman, Joanne D Stockton, Boris Noyvert, Andrew D Beggs, Michelle J West, Sally Roberts, Joanna L Parish
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2018-10-01
coleção:PLoS Biology
Acesso em linha:https://doi.org/10.1371/journal.pbio.2005752
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