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MicroRNA profiling in post-mortem spinal cord of C9ORF72-related ALS patients reveals molecular pathways involved in motor neuron degeneration

IntroductionAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder causing progressive motor neuron death in cortex, brainstem and spinal cord. The most common genetic cause is the G4C2 hexanucleotide repeat expansion in the non-coding region of exon 1 of C9ORF72, accounting for ~...

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Principais autores: Giorgia Farinazzo, Eleonora Giagnorio, Matteo Marcuzzo, Marco Cattaneo, Claudia Malacarne, Paola Cavalcante, Silvia Bonanno, Emanuela Maderna, Viviana Pensato, Cinzia Gellera, Gianluca Marucci, Samanta Mazzetti, Erika Salvi, Giuseppe Lauria, Stefania Marcuzzo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-01-01
Serier:Frontiers in Neuroscience
Fag:
C9ORF72-amyotrophic lateral sclerosis
human post-mortem spinal cord tissue
microRNAs
motor neuron
target genes
Online adgang:https://www.frontiersin.org/articles/10.3389/fnins.2026.1741065/full
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