TRAIL Activates a Caspase 9/7-Dependent Pathway in Caspase 8/10-Defective SK-N-SH Neuroblastoma Cells with Two Functional End Points: Induction of Apoptosis and PGE2 Release

Most neuroblastoma cell lines do not express apical caspases 8 and 10, which play a key role in mediating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in a variety of malignant cell types. In this study, we demonstrated that TRAIL induced a moderate but significant in...

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Detalhes bibliográficos

Principais autores:	Giorgio Zauli, Daniela Milani, Erika Rimondi, Giovanna Baldini, Vanessa Nicolin, Vittorio Grill, Paola Secchiero
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2003-09-01
Colecção:	Neoplasia: An International Journal for Oncology Research
Assuntos:	TRAIL cell death caspases neuroblastoma prostanoids
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1476558603800489
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