Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors
Abstract Background Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delivered prior to (rather than after) CDK4/6 inhibition. Depending on tumor...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMC
2023-02-01
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| Schriftenreihe: | Journal of Translational Medicine |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1186/s12967-023-03964-4 |
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